Open Access<p>3D-HA Scaffold Functionalized by Extracellular Matrix of Stem Cells Promotes Bone Repair</p>
Author(s) -
Hui Chi,
Guanghua Chen,
Yizhu He,
Guanghao Chen,
Hualei Tu,
Xiaoqi Liu,
Jinglong Yan,
Xiaoyan Wang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259678
Subject(s) - scaffold , extracellular matrix , biomedical engineering , biocompatibility , mesenchymal stem cell , regenerative medicine , materials science , tissue engineering , bone healing , in vivo , chemistry , adhesion , regeneration (biology) , cell , microbiology and biotechnology , anatomy , composite material , medicine , biology , biochemistry , metallurgy
The extracellular matrix (ECM) derived from bone marrow mesenchymal stem cells (BMSCs) has been used in regenerative medicine because of its good biological activity; however, its poor mechanical properties limit its application in bone regeneration. The purpose of this study is to construct a three dimensional-printed hydroxyapatite (3D-HA)/BMSC-ECM composite scaffold that not only has biological activity but also sufficient mechanical strength and reasonably distributed spatial structure.