Open Access<p>Comparative Encapsulation Efficiency of Lutein in Micelles Synthesized via Batch and High Throughput Methods</p>
Author(s) -
Lauren E. Cosby,
Kil Ho Lee,
Thomas J. Knobloch,
Christopher M. Weghorst,
Jessica Winter
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259202
Subject(s) - bioavailability , sonication , micelle , polyethylene glycol , lutein , chemistry , nanocapsules , materials science , nanoparticle , chromatography , nanotechnology , biochemistry , pharmacology , organic chemistry , carotenoid , aqueous solution , biology
Black raspberries (BRBs) and their anthocyanin-rich hydrophilic fractions (BRB-H) have exhibited significant chemopreventative activity across aerodigestive cancers. Lutein, the primary component of the BRB lipophilic fraction (BRB-L), also demonstrates bioactivity potential, but is less well characterized, in part because of its poor, innate bioavailability. For these lipophilic compounds to be accurately evaluated for anticancer efficacy, it is necessary to increase their functional bioavailability using delivery vehicles. Lutein has been delivered in commercial settings in emulsion form. However, emulsions are unstable, particularly in the gastrointestinal tract, which limit their use as an oral nutraceutical. Here, we evaluated lutein encapsulation and cellular uptake for nanoparticle (NP) delivery vehicles composed of three different materials synthesized via two different approaches.