Open Access<p>Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies</p>
Author(s) -
Amira Yousry Farrah,
Abdulaziz Mohsen Al-mahallawi,
Emad B. Basalious,
Demiana I. Nesseem
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259172
Subject(s) - zeta potential , ex vivo , nanocarriers , drug delivery , permeation , phosphatidylcholine , nanocapsules , dispersity , drug carrier , materials science , in vivo , pharmacology , chemistry , nanotechnology , biophysics , biomedical engineering , nanoparticle , phospholipid , membrane , in vitro , medicine , biochemistry , polymer chemistry , microbiology and biotechnology , biology
Drug delivery into the inner ear across the intact tympanic membrane (TM) has been a challenge in the treatment of inner ear disorders. In this study, nano-sized carriers were formulated for improving the non- invasive oto-topical delivery of caroverine for the treatment of tinnitus.