Open Access<p>Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice</p>
Author(s) -
Xun Yuan,
Zhenshuai Fu,
Pengfei Ji,
Lu-Bo Guo,
Ali O. Al-Ghamdy,
Ali Alkandiri,
Ola A. Habotta,
Ahmed E. Abdel Moneim,
Rami B. Kassab
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259134
Subject(s) - neuroprotection , oxidative stress , pharmacology , neurochemical , epilepsy , anticonvulsant , seizure threshold , valproic acid , glutathione , proinflammatory cytokine , convulsion , hippocampal formation , chemistry , medicine , neuroinflammation , endocrinology , inflammation , biochemistry , psychiatry , enzyme
Epilepsy is a chronic neurological condition characterized by behavioral, molecular, and neurochemical alterations. Current antiepileptic drugs are associated with various adverse impacts. The main goal of the current study is to investigate the possible anticonvulsant effect of selenium nanoparticles (SeNPs) against pentylenetetrazole (PTZ)-mediated epileptic seizures in mice hippocampus. Sodium valproate (VPA) was used as a standard anti-epileptic drug.