Open Access<p>Electrospun Fibers Immobilized with BMP-2 Mediated by Polydopamine Combined with Autogenous Tendon to Repair Developmental Dysplasia of the Hip in a Porcine Model</p>
Author(s) -
Ruiqi Wu,
Guanying Gao,
Yan Xu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259028
Subject(s) - biocompatibility , electrospinning , alkaline phosphatase , chemistry , mesenchymal stem cell , masson's trichrome stain , biomedical engineering , staining , tissue engineering , in vivo , bone morphogenetic protein 2 , in vitro , pathology , biochemistry , medicine , biology , polymer , enzyme , microbiology and biotechnology , organic chemistry
Developmental dysplasia of the hip (DDH) can increase the pressure between the joints, which causes secondary hip osteoarthritis. The aim of the present study was to fabricate poly(D, L-lactic acid)-poly(ethylene glycol)-poly(D, L-lactic acid) (PELA) electrospun fibrous scaffolds, immobilized with bone morphogenetic protein-2 (BMP-2), to repair the acetabulum defects.