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Cerium oxide nanoparticles (CeO 2 NPs) are potent scavengers of cellular reactive oxygen species (ROS). Their antioxidant properties make CeO 2 NPs promising therapeutic agents for bone diseases and bone tissue engineering. However, the effects of CeO 2 NPs on intracellular ROS production in osteoclasts (OCs) are still unclear. Numerous studies have reported that intracellular ROS are essential for osteoclastogenesis. The aim of this study was to explore the effects of CeO 2 NPs on osteoclast differentiation and the potential underlying mechanisms.

international journal of nanomedicine

&lt;p&gt;Cerium Oxide Nanoparticles Regulate Osteoclast Differentiation Bidirectionally by Modulating the Cellular Production of Reactive Oxygen Species&lt;/p&gt;