Open Access<p>Cerium Oxide Nanoparticles Regulate Osteoclast Differentiation Bidirectionally by Modulating the Cellular Production of Reactive Oxygen Species</p>
Author(s) -
Kai Yuan,
Jingtian Mei,
Dandan Shao,
Feng Zhou,
Han Qiao,
Yuhua Liang,
Kai Li,
Tingting Tang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s257741
Subject(s) - osteoclast , reactive oxygen species , microbiology and biotechnology , rankl , chemistry , tunel assay , apoptosis , intracellular , cellular differentiation , activator (genetics) , biochemistry , receptor , biology , gene
Cerium oxide nanoparticles (CeO 2 NPs) are potent scavengers of cellular reactive oxygen species (ROS). Their antioxidant properties make CeO 2 NPs promising therapeutic agents for bone diseases and bone tissue engineering. However, the effects of CeO 2 NPs on intracellular ROS production in osteoclasts (OCs) are still unclear. Numerous studies have reported that intracellular ROS are essential for osteoclastogenesis. The aim of this study was to explore the effects of CeO 2 NPs on osteoclast differentiation and the potential underlying mechanisms.