Open Access<p>Dual-Effect of Magnetic Resonance Imaging Reporter Gene in Diagnosis and Treatment of Hepatocellular Carcinoma</p>
Author(s) -
Jian Zhou,
Qiao-Mei Zhou,
Shu Gao,
Xiaojie Wang,
YuanFei Lu,
Haiyan Chen,
Tingting Hu,
Jinsong Cai,
YongZhong Du,
RiSheng Yu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s257628
Subject(s) - transfection , hepatocellular carcinoma , transferrin receptor , transferrin , microbiology and biotechnology , flow cytometry , reporter gene , ferritin , western blot , cancer research , in vivo , intracellular , chemistry , biology , cell culture , medicine , gene expression , pathology , gene , biochemistry , genetics
The early diagnosis of hepatocellular carcinoma (HCC) with ferritin heavy chain (Fth) modified by alpha-fetoprotein (AFP) promoter has been studied. However, no study has focused on the considerable upregulation and specific targeting effects of transferrin receptors (TfR) caused by the transfection of plasmids encoded with the AFP promoter. Thus, the objective of our study was to investigate whether the transfection of Fth gene modified with AFP promoter (AFP@Fth) could be used for early diagnosis and enhanced treatment of HCC.