Open Access<p>Novel T7-Modified pH-Responsive Targeted Nanosystem for Co-Delivery of Docetaxel and Curcumin in the Treatment of Esophageal Cancer</p>
Author(s) -
Lian Deng,
Xiongjie Zhu,
Zhongjian Yu,
Ying Li,
Lijie Qin,
Zhile Liu,
Longbao Feng,
Rui Guo,
Yanfang Zheng
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s257312
Subject(s) - curcumin , docetaxel , pharmacology , esophageal cancer , cancer , cancer research , medicine , chemistry , nanotechnology , materials science
Although single-drug chemotherapy is still an effective treatment for esophageal cancer, its long-term application is limited by severe side-effects, poor bioavailability, and drug-resistance. Increasing attention has been paid to nanomedicines because of their good biological safety, targeting capabilities, and high-efficiency loading of multiple drugs. Herein, we have developed a novel T7 peptide-modified pH-responsive targeting nanosystem co-loaded with docetaxel and curcumin for the treatment of esophageal cancer.