Open Access<p>Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T2 Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents</p>
Author(s) -
Mateusz Michał Tomczyk,
Sławomir Boncel,
Artur P. Herman,
Tomasz Krawczyk,
Agata JakóbikKolon,
Mirosława Pawlyta,
Maciej Krzywiecki,
A. Chrobak,
Masafumi Minoshima,
Fuminori Sugihara,
Kazuya Kikuchi,
Nikodem Kuźnik
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s257230
Subject(s) - surface modification , biocompatibility , materials science , carbon nanotube , oxygen , nanotechnology , superparamagnetism , chemical engineering , chemistry , organic chemistry , magnetization , physics , engineering , quantum mechanics , magnetic field , metallurgy
Salicyl (Sal) - among other oxygen functionalities - multi-walled carbon nanotubes (MWCNTs) and their nanohybrids are investigated as promising contrast agents (CA) in magnetic resonance imaging (MRI) or drug delivery platforms, due to their unique properties. The preliminary results and the literature reports were the motivation to endow high r 2 relaxivities, excellent dispersibility in water, and biocompatibility to superparamagnetic MWCNTs nanohybrids. It was hypothesized that these goals could be achieved by, not described in the literature yet, two-stage oxygen functionalization of MWCNTs.