Open Access<p>Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers</p>
Author(s) -
Tarek A. Ahmed,
Alaa O Bawazir,
Waleed S. Alharbi,
Martin K. Safo
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s256925
Subject(s) - permeation , bioavailability , ex vivo , buccal administration , materials science , solubility , drug carrier , chromatography , chemistry , pharmacokinetics , drug delivery , pharmacology , nanotechnology , organic chemistry , in vitro , medicine , biochemistry , membrane
Simvastatin (SMV), a hypocholesterolemic agent, suffers from very low bioavailability due to its poor aqueous solubility and extensive first-pass metabolism.