Open Access<p>Guiding Appropriate Timing of Laser Irradiation by Polymeric Micelles for Maximizing Chemo-Photodynamic Therapy</p>
Author(s) -
Yun Zhu,
Fangying Yu,
Yanan Tan,
Lijuan Wen,
Yinghong Li,
Hong Yuan,
Fuqiang Hu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s256477
Subject(s) - phototoxicity , photodynamic therapy , photosensitizer , in vivo , biophysics , fluorescence , doxorubicin , irradiation , glutathione , chemistry , materials science , photochemistry , in vitro , medicine , biochemistry , organic chemistry , chemotherapy , biology , surgery , optics , physics , microbiology and biotechnology , nuclear physics , enzyme
Photoactivity "on-off" switchable nano-agents could shield phototoxicity until reaching target region, which immensely promoted photodynamic therapy. However, the masking ratio of nano-agents in vivo was dynamic and positively correlated with the phototoxicity induced by laser irradiation, in which case the timing of laser irradiation was unpredictable to maximize antitumor efficacy.