Open Access<p>TAT-Modified Gold Nanoparticles Enhance the Antitumor Activity of PAD4 Inhibitors</p>
Author(s) -
Songlin Song,
Lin Gui,
Qiqi Feng,
Ayijiang Taledaohan,
Yuanming Li,
Wei Wang,
Yanming Wang,
Yuji Wang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s255546
Subject(s) - in vivo , colloidal gold , apoptosis , autophagy , chemistry , in vitro , peptide , cancer cell , cancer research , pharmacology , biochemistry , biology , cancer , materials science , nanoparticle , nanotechnology , genetics , microbiology and biotechnology
Histone citrullination by peptidylarginine deiminases 4 (PAD4) regulates the gene expression of tumor suppressor. In our previously study, YW3-56 (356) was developed as a potent PAD4 inhibitor for cancer therapy with novel function in the autophagy pathway. To enhance the antitumor activity, the PAD4 inhibitor 356 was modified by the well-established cationic penetrating peptide RKKRRQRRR (peptide TAT) and gold nanoparticles to obtain 356-TAT-AuNPs which could enhance the permeability of chemical drug in solid tumor.