Open Access<p>Anti-Oxidant and Anti-Endothelial Dysfunctional Properties of Nano-Selenium in vitro and in vivo of Hyperhomocysteinemic Rats</p>
Author(s) -
Zeqi Zheng,
Lijuan Liu,
Kaiwen Zhou,
Liang Ding,
Junyi Zeng,
Wan Zhang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s255392
Subject(s) - hyperhomocysteinemia , endothelial dysfunction , homocysteine , glutathione peroxidase , in vivo , endothelial stem cell , gpx1 , pharmacology , oxidative stress , in vitro , chemistry , medicine , endocrinology , superoxide dismutase , biology , biochemistry , microbiology and biotechnology
Elevation of blood homocysteine (Hcy) level (hyperhomocysteinemia) is a risk factor for cardiovascular disorders and is closely associated with endothelial dysfunction. The present study aims to investigate the protective effect and underlying mechanism of nanoscale selenium (Nano-Se) in Hcy-mediated vascular endothelial cell dysfunction in vitro and in vivo.