Open Access<p>Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation</p>
Author(s) -
Muhammad Hanif,
Shahid Shah,
Akhtar Rasul,
Ghulam Abbas,
Muhammad Zaman,
Muhammad Wahab Amjad,
Maria Abdul Ghafoor Raja,
Hafeez Ullah Khan,
Mehran Ashfaq,
Omeira Iqbal
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s255278
Subject(s) - bioavailability , pharmacokinetics , raft , cmax , chemistry , zeta potential , nuclear chemistry , particle size , pharmacology , materials science , chromatography , polymer , medicine , nanoparticle , organic chemistry , nanotechnology , copolymer
Bisphosphonates have very low bioavailability and cause irritation of the esophagus and stomach. This study was planned to improve the oral bioavailability of ibandronate through the formation of a raft in the stomach. Bisphosphonate-induced irritation of the esophagus and stomach is prevented by the formation of a raft.