Open Access<p>Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury</p>
Author(s) -
Fawzi Babiker,
İbrahim F. Benter,
Saghir Akhtar
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s255202
Subject(s) - ex vivo , medicine , in vivo , reperfusion injury , cardiac function curve , ischemia , pharmacology , contractility , hemodynamics , anesthesia , heart failure , biology , microbiology and biotechnology
The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac function in control and diabetic rat hearts following ischemia-reperfusion (I/R) injury.