Open Access<p>Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells</p>
Author(s) -
Ewelina Piktel,
Karolina H. Markiewicz,
Agnieszka Z. Wilczewska,
Tamara Daniluk,
Sylwia Chmielewska,
Katarzyiemirowicz-Laskowska,
Joanna Mystkowska,
Paulina Paprocka,
Paul B. Savage,
Robert Bucki
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s255170
Subject(s) - nanoparticle , iron oxide nanoparticles , chemistry , flow cytometry , magnetic nanoparticles , cancer cell , covalent bond , pharmacology , in vitro , viability assay , cancer , biophysics , nuclear chemistry , nanotechnology , cancer research , materials science , biochemistry , microbiology and biotechnology , medicine , organic chemistry , biology
Therapeutic efficiency of ceragenins against cancers may be limited by lack of their hemocompatibility when high concentrations of molecules are required to reach a desired result. Synergistic effects observed upon administration of anticancer agents and metal nanoparticles may provide an opportunity to limit toxicity of immobilized ceragenins on the surface of metal nanoparticles and to improve their therapeutic efficiency at the same time. The aim of present work is to investigate the anticancer activities and hemocompatibility of nanoformulations consisting of ceragenin CSA-131 united with aminosilane-modified iron oxide-based magnetic nanoparticles (MNP) and prepared by 1) covalent bonding (MNP@CSA-131) or 2) by combining CSA-131 with MNP in 1:1 ratio (CSA-131 + MNP). Possible synergistic interactions between CSA-131 and magnetic nanoparticles were also quantified.