Open Access<p>Enhanced Efficacy of Photodynamic Therapy by Coupling a Cell-Penetrating Peptide with Methylene Blue</p>
Author(s) -
Jinhui Ser,
Ji Yeon Lee,
Yong Ho Kim,
Hoonsung Cho
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s254881
Subject(s) - photodynamic therapy , photosensitizer , methylene blue , viability assay , chemistry , protamine , lysosome , cell penetrating peptide , programmed cell death , cytotoxicity , hela , mtt assay , biophysics , cell , apoptosis , biochemistry , in vitro , biology , photochemistry , heparin , organic chemistry , photocatalysis , enzyme , catalysis
Photodynamic therapy (PDT), which induces tissue damage by exposing tissue to a specific wavelength of light in the presence of a photosensitizer and oxygen, is a promising alternative treatment that could be used as an adjunct to chemotherapy and surgery in oncology. Cell-penetrating peptides (CPPs) with high arginine content, such as protamine, have membrane translocation and lysosome localization activities. They have been used in an extensive range of drug delivery applications.