Open Access<p>A New Pharmacokinetic Model Describing the Biodistribution of Intravenously and Intratumorally Administered Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in a GL261 Xenograft Glioblastoma Model</p>
Author(s) -
A.P. Klapproth,
Maxim Shevtsov,
Stefan Stangl,
Wei Bo Li,
Gabriele Multhoff
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s254745
Subject(s) - biodistribution , pharmacokinetics , in vivo , pharmacology , distribution (mathematics) , drug delivery , nanoparticle , glioma , spleen , materials science , medicine , cancer research , biomedical engineering , nanotechnology , immunology , biology , mathematical analysis , microbiology and biotechnology , mathematics
Superparamagnetic iron oxide nanoparticles (SPIONs) have displayed multifunctional applications in cancer theranostics following systemic delivery. In an effort to increase the therapeutic potential of local therapies (including focal hyperthermia), nanoparticles can also be administered intratumorally. Therefore, the development of a reliable pharmacokinetic model for the prediction of nanoparticle distribution for both clinically relevant routes of delivery is of high importance.