Open Access<p>Iron(II) phthalocyanine Loaded and AS1411 Aptamer Targeting Nanoparticles: A Nanocomplex for Dual Modal Imaging and Photothermal Therapy of Breast Cancer</p>
Author(s) -
Yubei He,
Mengzhu Wang,
Ming Fu,
Xun Yuan,
Yuanli Luo,
Bin Qiao,
Jin Cao,
Zhigang Wang,
Hao Lu,
Yuan Gao
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s254108
Subject(s) - photothermal therapy , in vivo , biocompatibility , nanomedicine , aptamer , materials science , cancer research , imaging agent , nanotechnology , in vitro , breast cancer , cancer , nanoparticle , biomedical engineering , chemistry , medicine , microbiology and biotechnology , biochemistry , biology , metallurgy
A multi-functional nanoplatform with diagnostic imaging and targeted treatment functions has aroused much interest in the nanomedical research field and has been paid more attention in the field of tumor diagnosis and treatment. However, some existing nano-contrast agents have encountered difficulties in different aspects during clinical promotion, such as complicated preparation process and low specificity. Therefore, it is urgent to find a nanocomplex with good targeting effect, high biocompatibility and significant therapeutic effect for the integration of diagnosis and treatment and clinical transformation.