Open Access<p>Cascade-Targeting of Charge-Reversal and Disulfide Bonds Shielding for Efficient DOX Delivery of Multistage Sensitive MSNs-COS-SS-CMC</p>
Author(s) -
Lan Cui,
Wentao Liu,
Hao Líu,
Q. Qin,
Shuangxia Wu,
Suqin He,
Zhenya Zhang,
Xinchang Pang,
Chengshen Zhu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s252769
Subject(s) - endocytosis , biophysics , internalization , in vitro , drug delivery , chemistry , cancer research , pharmacology , biochemistry , nanotechnology , materials science , medicine , cell , biology
Although pH and redox sensitiveness have been extensively investigated to improve therapeutic efficiency, the effect of disulfide bonds location and pH-triggered charge-reversal on cascade-targeting still need to be further evaluated in cancer treatment with multi-responsive nanoparticles.