Open Access<p>The Immunoenhancement Effects of Polyethylenimine-Modified Chinese Yam Polysaccharide-Encapsulated PLGA Nanoparticles as an Adjuvant</p>
Author(s) -
Yue Zhang,
Peng Gu,
Adelijiang Wusiman,
Shuwen Xu,
Haiyu Ni,
Tianxin Qiu,
Zhenguang Liu,
Yuanliang Hu,
Jiaguo Liu,
Deyun Wang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s252515
Subject(s) - polyethylenimine , plga , adjuvant , antigen , cd80 , immune system , in vivo , in vitro , chemistry , materials science , immunology , biology , biochemistry , transfection , cytotoxic t cell , cd40 , microbiology and biotechnology , gene
Poly(lactic-co-glycolic acid) (PLGA) has been extensively applied for sustained drug delivery and vaccine delivery system. However, vaccines delivered by PLGA nanoparticles alone could not effectively activate antigen-presenting cells (APCs) to induce strong immune responses.