Open Access<p>Evidence Supporting the Safety of Pegylated Diethylaminoethyl-Chitosan Polymer as a Nanovector for Gene Therapy Applications</p>
Author(s) -
Elsa Patricia Rondon,
Houda Abir Benabdoun,
Francis Vallières,
Maicon Segalla Petrônio,
Márcio José Tiera,
Mohamed Benderdour,
Julio Fernandes
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s252397
Subject(s) - hemolysis , peripheral blood mononuclear cell , polyethylene glycol , chemistry , chitosan , peg ratio , pharmacology , viability assay , in vitro , microbiology and biotechnology , biochemistry , immunology , medicine , biology , finance , economics
Diethylaminoethyl-chitosan (DEAE-CH) is a derivative with excellent potential as a delivery vector for gene therapy applications. The aim of this study is to evaluate its toxicological profile for potential future clinical applications.