Open Access<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>
Author(s) -
Saeid Maghsoudi,
Bahareh Taghavi Shahraki,
Navid Rabiee,
Yousef Fatahi,
Rassoul Dinarvand,
Maryam Tavakolizadeh,
Sepideh Ahmadi,
Mohammad Rabiee,
Mojtaba Bagherzadeh,
Ali Pourjavadi,
Hassan Farhadnejad,
Mohammadreza Tahriri,
Thomas J. Webster,
Lobat Tayebi
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s252237
Subject(s) - drug delivery , natural polymers , plga , nanotechnology , biocompatibility , materials science , biodegradable polymer , polymer , chitosan , glycolic acid , lactic acid , biochemical engineering , chemistry , nanoparticle , organic chemistry , biology , engineering , bacteria , genetics , metallurgy , composite material
With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.