Open Access<p>Polyphenol-Conjugated Bimetallic Au@AgNPs for Improved Wound Healing</p>
Author(s) -
Piotr Orłowski,
Magdalena Żmigrodzka,
Emilia Tomaszewska,
Katarzyna RanoszekSoliwoda,
Beata Pająk,
Anna Słońska,
Joanna Cymerys,
Grzegorz Celichowski,
Jarosław Grobelny,
Małgorzata Krzyżowska
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s252027
Subject(s) - tannic acid , gallic acid , hacat , chemistry , wound healing , polyphenol , epigallocatechin gallate , resveratrol , granulation tissue , in vivo , epicatechin gallate , biochemistry , antioxidant , pharmacology , nuclear chemistry , in vitro , organic chemistry , medicine , biology , microbiology and biotechnology , immunology
Polyphenols possess antioxidant, anti-inflammatory and antimicrobial properties and have been used in the treatment of skin wounds and burns. We previously showed that tannic acid-modified AgNPs sized >26 nm promote wound healing, while tannic acid-modified AgNPs sized 13 nm can elicit strong local inflammatory response. In this study, we tested bimetallic Au@AgNPs sized 30 nm modified with selected flavonoid and non-flavonoid compounds for wound healing applications.