Open Access<p>Overcoming Multiple Absorption Barrier for Insulin Oral Delivery Using Multifunctional Nanoparticles Based on Chitosan Derivatives and Hyaluronic Acid</p>
Author(s) -
Zuxian Chen,
Shangcong Han,
Xiaotang Yang,
Lisa X. Xu,
Hong Qi,
Guizhou Hao,
Jie Cao,
Yan Liang,
Qingming Ma,
Guimin Zhang,
Yong Sun
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s251627
Subject(s) - paracellular transport , hyaluronic acid , in vivo , chitosan , biophysics , insulin , absorption (acoustics) , chemistry , pinocytosis , endocytosis , bioavailability , caco 2 , pharmacology , biochemistry , in vitro , cell , membrane , materials science , medicine , biology , microbiology and biotechnology , composite material , permeability (electromagnetism) , endocrinology , anatomy
Although dynamics and uses of modified nanoparticles (NPs) as orally administered macromolecular drugs have been researched for many years, measures of molecule stability and aspects related to important transport-related mechanisms which have been assessed in vivo remain as relatively under characterized. Thus, our aim was to develop a novel type of oral-based delivery system for insulin and to overcome barriers to studying the stability, transport mechanisms, and efficacy in vivo of the delivery system.