Open Access<p>Enhanced Percutaneous Delivery of Methotrexate Using Micelles Prepared with Novel Cationic Amphipathic Material</p>
Author(s) -
Yunchun Zhao,
Haili Zheng,
Xiaorong Wang,
Xiaojiao Zheng,
Yue Chen,
Weidong Fei,
Yongquan Zheng,
Wenxi Wang,
Caihong Zheng
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s251431
Subject(s) - micelle , transdermal , amphiphile , cationic polymerization , zeta potential , critical micelle concentration , chemistry , phosphatidylcholine , permeation , drug delivery , nuclear chemistry , drug carrier , organic chemistry , materials science , chromatography , aqueous solution , copolymer , pharmacology , nanoparticle , phospholipid , membrane , biochemistry , nanotechnology , medicine , polymer
Methotrexate (MTX) is an antiproliferative drug widely used to treat inflammatory diseases and autoimmune diseases. The application of percutaneous administration is hindered due to its poor transdermal penetration. To reduce side effects and enhanced percutaneous delivery of MTX, novel methotrexate (MTX)-loaded micelles prepared with a amphiphilic cationic material, N,N -dimethyl-( N',N' -di-stearoyl-1-ethyl)1,3-diaminopropane (DMSAP), was designed.