Open Access<p>Honokiol-mesoporous Silica Nanoparticles Inhibit Vascular Restenosis via the Suppression of TGF-β Signaling Pathway</p>
Author(s) -
Xiao Wei,
Zhiwei Fang,
Jifang Sheng,
Yu Wang,
Ping Lü
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s250911
Subject(s) - restenosis , honokiol , neointimal hyperplasia , intimal hyperplasia , mesoporous silica , vascular smooth muscle , neointima , pharmacology , materials science , medicine , chemistry , stent , mesoporous material , biochemistry , smooth muscle , catalysis
The main pathological mechanism of restenosis after percutaneous coronary intervention (PCI) is intimal hyperplasia, which is mainly caused by proliferation and migration of vascular smooth muscle cells (VSMCs). Our previous study found that honokiol (HNK), a small-molecule polyphenol, can inhibit neointimal hyperplasia after balloon injury, but its specific mechanism is still unclear. Moreover, poor water solubility as well as low bioavailability of honokiol has limited its practical use.