Open Access<p>A pH-Sensitive Prodrug Nanocarrier Based on Diosgenin for Doxorubicin Delivery to Efficiently Inhibit Tumor Metastasis</p>
Author(s) -
Zeliang Wei,
Haibo Wang,
Guang Xin,
Zhi Zeng,
Shiyi Li,
Yue Ming,
Xiaoyu Zhang,
Zhihua Xing,
Li Li,
YouPing Liu,
Boli Zhang,
Junhua Zhang,
Hai Niu,
Wen Huang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s250549
Subject(s) - nanocarriers , prodrug , doxorubicin , diosgenin , pharmacology , metastasis , cancer research , drug delivery , chemistry , materials science , medicine , nanotechnology , drug , cancer , chemotherapy , organic chemistry
The metastasis, one of the biggest barriers in cancer therapy, is the leading cause of tumor deterioration and recurrence. The anti.-metastasis has been considered as a feasible strategy for clinical cancer management. It is well known that diosgenin could inhibit tumor metastasis and doxorubicin (DOX) could induce tumor apoptosis. However, their efficient delivery remains challenging.