Open Access<p>Potential of Methylglyoxal-Conjugated Chitosan Nanoparticles in Treatment of Fluconazole-Resistant <em>Candida albicans</em> Infection in a Murine Model</p>
Author(s) -
Shaheer H. Khan,
Hina Younus,
Khaled S. Allemailem,
Ahmad Almatroudi,
Faris Alrumaihi,
Abdulmohsen M. Alruwetei,
Mohammed A Alsahli,
Arif Khan,
Masood Alam Khan
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s249625
Subject(s) - fluconazole , candida albicans , methylglyoxal , corpus albicans , pharmacology , toxicity , azole , microbiology and biotechnology , chemistry , kidney , medicine , biology , antifungal , biochemistry , enzyme
Fungal infections are becoming more prevalent and threatening because of the continuous emergence of azole-resistant fungal infections. The present study was aimed to assess the activity of free Methylglyoxal (MG) or MG-conjugated chitosan nanoparticles (MGCN) against fluconazole-resistant Candida albicans .