Open Access<p>ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy</p>
Author(s) -
Srinivasan Ayyanaar,
C. Balachandran,
R. Bhaskar,
Mookkandi Palsamy Kesavan,
Shin Aoki,
Ramachandran Palpandi Raja,
Jegathalaprathaban Rajesh,
Thomas J Webster,
Gurusamy Rajagopal
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s249240
Subject(s) - hela , cytotoxicity , cancer cell , drug delivery , chitosan , reactive oxygen species , cancer , mtt assay , pharmacology , targeted drug delivery , drug , iron oxide nanoparticles , ic50 , nanoparticle , chemistry , photodynamic therapy , cancer research , nanotechnology , materials science , in vitro , medicine , biochemistry , organic chemistry
Cancer cells accumulate high concentrations of reactive oxygen species as a result of their faster and uninhibited metabolic activity. Cancer chemotherapeutic agents release an excess of severe adverse reactions as a result of targeting normal cells. This demands an improvement in targeted drug-delivery systems to selectively discharge anticancer drugs in the vicinity of such highly metabolically and mitotically active cells.