Open Access<p>Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy</p>
Author(s) -
Yue Yang,
Yunjian Li,
Kai Chen,
Ling Zhang,
Sen Qiao,
Guoxin Tan,
Fen Chen,
Weisan Pan
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s249205
Subject(s) - hyaluronic acid , folic acid , micelle , folate receptor , redox , chemistry , biophysics , cancer , materials science , cancer cell , medicine , organic chemistry , aqueous solution , biology , anatomy
Poor site-specific delivery and insufficient intracellular drug release in tumors are inherent disadvantages to successful chemotherapy. In this study, an extraordinary polymeric micelle nanoplatform was designed for the efficient delivery of paclitaxel (PTX) by combining dual receptor-mediated active targeting and stimuli response to intracellular reduction potential.