Open Access<p>Oxygen Generating Polymeric Nano Fibers That Stimulate Angiogenesis and Show Efficient Wound Healing in a Diabetic Wound Model</p>
Author(s) -
Mubashra Zehra,
Waliya Zubairi,
Anwarul Hasan,
Hira Butt,
Amna Ramzan,
Maryam Azam,
Azra Mehmood,
Mojtaba Falahati,
Aqif Anwar Chaudhry,
Ihtesham Ur Rehman,
Muhammad Yar
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s248911
Subject(s) - wound healing , electrospinning , biomedical engineering , polycaprolactone , in vivo , angiogenesis , chorioallantoic membrane , extracellular matrix , wound dressing , materials science , medicine , chemistry , surgery , biochemistry , biology , cancer research , polymer , composite material , microbiology and biotechnology
Diabetic wounds are challenging to treat due to a wide range of pathophysiological changes. Hypoxia is one of the predominant contributing factors of poor vascularization and chronicity in diabetic wounds. This study was designed to develop polycaprolactone (PCL)-based oxygen-releasing electrospun wound dressings and evaluate their efficacy for improved full thickness wound healing in diabetic rats.