Open Access<p>Nanoparticle BAF312@CaP-NP Overcomes Sphingosine-1-Phosphate Receptor-1-Mediated Chemoresistance Through Inhibiting S1PR1/P-STAT3 Axis in Ovarian Carcinoma</p>
Author(s) -
Ke Gong,
Yang Dong,
Liting Wang,
Yi Duan,
Jian Yu,
Ying Sun,
Mingwen Bai,
Yourong Duan
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s248667
Subject(s) - s1pr1 , ovarian cancer , paclitaxel , stat3 , sphingosine , cancer research , ovarian carcinoma , chemistry , pharmacology , signal transduction , receptor , biology , medicine , cancer , biochemistry , vascular endothelial growth factor a , vascular endothelial growth factor , vegf receptors
Platinum/paclitaxel-based chemotherapy is the strategy for ovarian cancer, but chemoresistance, inherent or acquired, occurs and hinders therapy. Therefore, further understanding of the mechanisms of drug resistance and adoption of novel therapeutic strategies are urgently needed.