Open Access<p>Gold Nanoparticles Perturb Drug-Metabolizing Enzymes and Antioxidants in the Livers of Male Rats: Potential Impact on Drug Interactions</p>
Author(s) -
Mohammed Y I Al-Hamadani,
Abdullah M. Alzahrani,
Mokhtar I. Yousef,
Maher A. Kamel,
Wael M. ElSayed
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s248194
Subject(s) - colloidal gold , pharmacology , chemistry , catalase , chitosan , glutathione , malondialdehyde , superoxide dismutase , drug , antioxidant , nanoparticle , biochemistry , enzyme , medicine , nanotechnology , materials science
With the wide applications of chitosan and gold nanoparticles in drug delivery and many consumer products, there is limited available information about their effects on drug-metabolizing enzymes (DMEs). Changes in DMEs could result in serious drug interactions. Therefore, this study aimed to investigate the effects of exposure to chitosan or gold nanoparticles on hepatic Phase I and II DMEs, liver function and integrity, oxidative damage and liver architecture in male rats.