Open Access<p>Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery</p>
Author(s) -
Yue Sun,
Lingjun Li,
Huichao Xie,
Yuzhen Wang,
Shuang Gao,
Li Zhang,
Fumin Bo,
Shanjing Yang,
Anjie Feng
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s247935
Subject(s) - solid lipid nanoparticle , paeonol , materials science , bioavailability , chromatography , in vivo , drug delivery , chemistry , pharmacology , nanotechnology , medicine , alternative medicine , microbiology and biotechnology , pathology , biology
Paeonol (PAE) is a potential central neuroprotective agent with poor water solubility and rapid metabolism in vivo. The key to improve the clinical application of PAE in the treatment of neurodegenerative diseases is to improve the brain delivery of it. The purpose of this study was to construct a paeonol-solid lipid nanoparticles-in situ gel (PAE-SLNs-ISG) drug delivery system based on nose-brain transport pathway.