Open Access<p>Nanotechnology-Based Cisplatin Intracellular Delivery to Enhance Chemo-Sensitivity of Ovarian Cancer</p>
Author(s) -
Barbara Bortot,
Maurizio Mongiat,
Erica Valencic,
Simeone Dal Monego,
Danilo Licastro,
Matteo Crosera,
Gianpiero Adami,
Enrico Rampazzo,
Giuseppe Ricci,
Federico Romano,
Giovanni Maria Severini,
Stefania Biffi
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s247114
Subject(s) - cisplatin , ovarian cancer , apoptosis , in vivo , flow cytometry , cytotoxicity , cancer research , intracellular , pharmacology , drug delivery , chemistry , chemotherapy , intraperitoneal injection , cancer , in vitro , medicine , biology , immunology , biochemistry , microbiology and biotechnology , organic chemistry
Platinum resistance is a major challenge in the management of ovarian cancer. Even low levels of acquired resistance at the cellular level lead to impaired response to cisplatin. In ovarian cancer intraperitoneal therapy, nanoparticle formulation can improve the cisplatin's pharmacokinetics and safety profile.