Open Access<p>Fabrication of Photo-Crosslinkable Poly(Trimethylene Carbonate)/Polycaprolactone Nanofibrous Scaffolds for Tendon Regeneration</p>
Author(s) -
Xing Li,
Honglin Chen,
Shuting Xie,
Ning Wang,
Sujuan Wu,
Yuyou Duan,
Minmin Zhang,
Lingling Shui
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s246966
Subject(s) - polycaprolactone , materials science , trimethylene carbonate , electrospinning , composite number , scaffold , tissue engineering , ultimate tensile strength , tendon , regeneration (biology) , adhesion , composite material , biomedical engineering , biomaterial , nanotechnology , surgery , polymer , polymerization , medicine , biology , microbiology and biotechnology
The treatment of tendon injuries remains a challenging problem in clinical due to their slow and insufficient natural healing process. Scaffold-based tissue engineering provides a promising strategy to facilitate tendon healing and regeneration. However, many tissue engineering scaffolds have failed due to their poor and unstable mechanical properties. To address this, we fabricated nanofibrous polycaprolactone/methacrylated poly(trimethylene carbonate) (PCL/PTMC-MA) composite scaffolds via electrospinning.