Open Access<p>Multifunctional Nanoparticles Encapsulating Astragalus Polysaccharide and Gold Nanorods in Combination with Focused Ultrasound for the Treatment of Breast Cancer</p>
Author(s) -
Jie Xiong,
Binglei Jiang,
Yong Luo,
Jianzhong Zhang,
Xuan Gao,
Die Xu,
Ying Du,
Hao Lu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s246447
Subject(s) - materials science , in vivo , tumor necrosis factor alpha , immune system , in vitro , cytokine , cancer research , chemistry , medicine , biology , immunology , biochemistry , microbiology and biotechnology
Focused ultrasound (FUS) is a noninvasive method to produce thermal and mechanical destruction along with an immune-stimulatory effect against cancer. However, FUS ablation alone appears insufficient to generate consistent antitumor immunity. In this study, a multifunctional nanoparticle was designed to boost FUS-induced immune effects and achieve systemic, long-lasting antitumor immunity, along with imaging and thermal enhancement.