Open Access<p>Artemisinin Loaded mPEG-PCL Nanoparticle Based Photosensitive Gelatin Methacrylate Hydrogels for the Treatment of Gentamicin Induced Hearing Loss</p>
Author(s) -
Xiaohua Li,
Yanchun Wang,
Fangming Xu,
Feng Zhang,
Ying Xu,
Lei Tang,
Thomas J Webster
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s245188
Subject(s) - gelatin , artemisinin , materials science , gentamicin , self healing hydrogels , nanoparticle , methacrylate , nuclear chemistry , pharmacology , polymer chemistry , chemistry , nanotechnology , composite material , medicine , copolymer , polymer , antibiotics , organic chemistry , plasmodium falciparum , biochemistry , malaria , immunology
Artemisinin (ART) is a natural anti-malarial sesquiterpene lactone which has the ability to treat and activate the CLRN1 pathway to play a pivotal role in hearing loss and hair cell function. To investigate the therapeutic effect of ART in hearing loss induced by gentamicin (GM), an ART-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) mPEG-PCL nanoparticle-based photosensitive hydrogel was developed and tested in this study.