Open Access<p>Eudragit<sup>®</sup>-S100 Coated PLGA Nanoparticles for Colon Targeting of Etoricoxib: Optimization and Pharmacokinetic Assessments in Healthy Human Volunteers</p>
Author(s) -
Enas El-Maghawry,
Mina Ibrahim Tadros,
Seham A. Elkheshen,
Ahmed Abdelbary
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s244124
Subject(s) - plga , etoricoxib , pharmacokinetics , nuclear chemistry , gelatin , nanoparticle , methacrylic acid , materials science , pharmacology , chemistry , medicine , copolymer , organic chemistry , nanotechnology , polymer
Etoricoxib is a selective inhibitor of COX-2 enzyme. It is proposed as a potent anti-inflammatory drug intended for the control of irritable bowel syndrome. The current work aimed at developing etoricoxib-loaded nanoparticles for colon- targeting.