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The bone regeneration of endosseous implanted biomaterials is often impaired by the host immune response, especially macrophage-related inflammation which plays an important role in the bone healing process. Thus, it is a promising strategy to design an osteo-immunomodulatory biomaterial to take advantage of the macrophage-related immune response and improve the osseointegration performance of the implant.

international journal of nanomedicine

&lt;p&gt;Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO&lt;sub&gt;2&lt;/sub&gt; Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy&lt;/p&gt;