Open Access<p>Exosome Derived from Coronary Serum of Patients with Myocardial Infarction Promotes Angiogenesis Through the miRNA-143/IGF-IR Pathway</p>
Author(s) -
Tao Geng,
Song Zhang,
Jingxian Xing,
Bingxun Wang,
Shipeng Dai,
Zesheng Xu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s242908
Subject(s) - exosome , angiogenesis , microvesicles , gene knockdown , medicine , microrna , microbiology and biotechnology , cancer research , umbilical vein , apoptosis , biology , gene , biochemistry , in vitro
Myocardial ischemia-reperfusion injury primarily causes myocardial infarction (MI), which is manifested by cell death. Angiogenesis is essential for repair and regeneration in cardiac tissue after MI. In this study, we aimed to investigate the effect of exosomes derived from the serum of MI patients in angiogenesis and its related mechanism.