Open Access<p><sup>99m</sup>Tc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation</p>
Author(s) -
Chong Huang,
Fen Chen,
Ling Zhang,
Yue Yang,
Xinggang Yang,
Wei-San Pan
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s242490
Subject(s) - curcumin , chemistry , cytotoxicity , biodistribution , in vivo , mtt assay , in vitro , dynamic light scattering , polyethylene glycol , drug delivery , pharmacology , nanoparticle , biochemistry , nanotechnology , materials science , medicine , organic chemistry , microbiology and biotechnology , biology
Emerging cancer therapy requires highly sensitive diagnosis in combination with cancer-targeting therapy. In this study, a self-assembled pH-sensitive curcumin (Cur)-loaded nanoparticle of 99m Tc radiolabeled hyaluronan-cholesteryl hemisuccinate conjugates (HA-CHEMS) and D-a-tocopheryl polyethylene glycol succinate (TPGS) was prepared for breast cancer synergistic theranostics.