Open Access<p>Preparation and in vitro and in vivo Study of Asiaticoside-Loaded Nanoemulsions and Nanoemulsions-Based Gels for Transdermal Delivery</p>
Author(s) -
Huimin Li,
Qian Peng,
Yong Guo,
Xiaohui Wang,
Li Zhang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s241923
Subject(s) - transdermal , stratum corneum , in vivo , ex vivo , bioavailability , pharmacology , pharmacokinetics , lipophilicity , permeation , poloxamer , penetration (warfare) , chemistry , biomedical engineering , chromatography , materials science , in vitro , medicine , stereochemistry , membrane , biochemistry , microbiology and biotechnology , pathology , copolymer , operations research , engineering , biology , polymer , organic chemistry
Asiaticoside (ASI), a compound of triterpene pentacyclic saponins, has apparently therapeutic efficacy on human hypertrophic scar. However, the characteristics of large molecular weight, low water solubility and poor lipophilicity do not favor the diffusion through the stratum corneum (SC). Therefore, it is expected that the development of a transdermally delivered formulation may enhance the permeability ratio (Qn) of ASI for its clinical application. In this study, we designed asiaticoside-loaded nanoemulsions (ASI-NEs) and nanoemulsions-based gels (ASI-NBGs) and studied their mechanism for transdermal delivery.