Open Access<p>Ultra-Small Lysozyme-Protected Gold Nanoclusters as Nanomedicines Inducing Osteogenic Differentiation</p>
Author(s) -
Kuo Li,
Pengfei Zhuang,
Bailong Tao,
Dan Li,
Xuejiao Xing,
Xifan Mei
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s241163
Subject(s) - osteoclast , microbiology and biotechnology , rankl , pi3k/akt/mtor pathway , cellular differentiation , protein kinase b , chemistry , signal transduction , biology , in vitro , biochemistry , activator (genetics) , gene
Ultra-small gold nanoclusters (AuNCs), as emerging fluorescent nanomaterials with excellent biocompatibility, have been widely investigated for in vivo biomedical applications. However, their effects in guiding osteogenic differentiation have not been investigated, which are important for osteoporosis therapy and bone regeneration. Herein, for the first time, lysozyme-protected AuNCs (Lys-AuNCs) are used to stimulate osteogenic differentiation, which have the potential for the treatment of bone disease.