Open Access<p>Noninvasive Molecular Imaging of the Enhanced Permeability and Retention Effect by <sup>64</sup>Cu-Liposomes: In vivo Correlations with <sup>68</sup>Ga-RGD, Fluid Pressure, Diffusivity and <sup>18</sup>F-FDG</p>
Author(s) -
Betina Børresen,
Anders Elias Hansen,
Frederikke P. Fliedner,
Jonas Rosager Henriksen,
Dennis Ringkjøbing Elema,
Malene Brandt-Larsen,
Lotte K. Kristensen,
Annemarie T. Kristensen,
Thomas Lars Andresen,
Andreas Kjær
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s239172
Subject(s) - liposome , in vivo , positron emission tomography , chemotherapy , medicine , electron paramagnetic resonance , nuclear medicine , magnetic resonance imaging , pharmacology , cancer research , biomedical engineering , materials science , biophysics , nuclear magnetic resonance , radiology , biology , nanotechnology , physics , microbiology and biotechnology
The accumulation of liposome encapsulated chemotherapy in solid cancers is dependent on the presence of the enhanced permeability and retention (EPR) effect. Positron emission tomography (PET) imaging with a liposome encapsulated radioisotope, such as liposome encapsulated Cu-64 ( 64 Cu-liposome) may help to identify tumors with high liposome accumulation, and thereby stratify patients based on expected benefit from liposomal chemotherapy. However, intravenous administration of liposomes without a cytotoxic content is complicated by the accelerated blood clearance (ABC) phenomenon for succeeding therapeutic liposome dosing. Alternative markers for assessing the tumor's EPR level are therefore warranted.