Open Access<p>Construction of Microunits by Adipose-Derived Mesenchymal Stem Cells Laden with Porous Microcryogels for Repairing an Acute Achilles Tendon Rupture in a Rat Model</p>
Author(s) -
Xuan Yang,
Hui Meng,
Jiang Peng,
Lijuan Xu,
Yu Wang,
Xiaojuan Sun,
Yun Zhao,
Qi Qi,
Weiyang Yu,
Mingxue Chen,
Tao Shi,
Yanan Du,
Shibi Lu,
Aiyuan Wang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s238399
Subject(s) - mesenchymal stem cell , achilles tendon , adipose tissue , tendon , stem cell , regeneration (biology) , tissue engineering , andrology , biomedical engineering , in vivo , anatomy , medicine , pathology , biology , microbiology and biotechnology
Tissue engineering approaches seem to be an attractive therapy for tendon rupture. Novel injectable porous gelatin microcryogels (GMs) can promote cell attachment and proliferation, thus facilitating the repair potential for target tissue regeneration. The research objectives of this study were to assess the efficacy of tissue-like microunits constructed by multiple GMs laden with adipose-derived mesenchymal stem cells (ASCs) in accelerated tendon regeneration in a rat model.