Open Access<p>Single- and Multi-Arm Gadolinium MRI Contrast Agents for Targeted Imaging of Glioblastoma</p>
Author(s) -
Rameshwar Patil,
Anna Galstyan,
Zachary B. Grodzinski,
Ekaterina S. Shatalova,
Shawn Wagner,
L. Israel,
Hui Ding,
Keith L. Black,
Julia Y. Ljubimova,
Eggehard Holler
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s238265
Subject(s) - gadolinium , magnetic resonance imaging , in vivo , mri contrast agent , glioma , chemistry , peptide , molecular imaging , nuclear magnetic resonance , biophysics , medicine , nuclear medicine , cancer research , biochemistry , radiology , biology , physics , microbiology and biotechnology , organic chemistry
Position of gadolinium atom(s) plays a key role in contrast enhancement of gadolinium-based contrast agents. To gain a better understanding of effects of distance of gadolinium in relation to the nanoconjugate platform, we designed and synthesized single- and multi-arm ("star") gadolinium conjugates equipped with antibody and peptides for targeting. The contrast agents were studied for their tumor imaging performance in a glioma mouse model.