Open Access<p>Aptamer-Conjugated Gold Nanoparticles Targeting Epidermal Growth Factor Receptor Variant III for the Treatment of Glioblastoma</p>
Author(s) -
Li Peng,
Yanling Liang,
Xinxin Zhong,
Zhiman Liang,
Yuan Tian,
Shuji Li,
Jingxue Liang,
Ransheng Wang,
Yuqi Zhong,
Yusheng Shi,
Xingmei Zhang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s238206
Subject(s) - aptamer , in vivo , epidermal growth factor receptor , u87 , colloidal gold , in vitro , cell culture , cell growth , cancer research , conjugated system , cell , glioblastoma , chemistry , microbiology and biotechnology , receptor , nanoparticle , materials science , medicine , nanotechnology , biology , biochemistry , genetics , organic chemistry , polymer
In this study, we constructed novel brain-targeting complexes (U2-AuNP) by conjugating aptamer U2 to the gold nanoparticle (AuNPs) surface as a promising option for GBM therapy.