Open Access<p>An in vitro Model System for Evaluating Remote Magnetic Nanoparticle Movement and Fibrinolysis</p>
Author(s) -
Sebastian Pernal,
Alexander Willis,
Michael Sabo,
Laura M Moore,
Steven T. Olson,
Sean C. Morris,
Francis M Creighton,
Herbert H. Engelhard
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s237395
Subject(s) - fibrinolysis , thrombus , biomedical engineering , tissue plasminogen activator , in vitro , materials science , magnetic nanoparticles , drug delivery , t plasminogen activator , fibrinolytic agent , nanoparticle , medicine , nanotechnology , chemistry , surgery , biochemistry
Thrombotic events continue to be a major cause of morbidity and mortality worldwide. Tissue plasminogen activator (tPA) is used for the treatment of acute ischemic stroke and other thrombotic disorders. Use of tPA is limited by its narrow therapeutic time window, hemorrhagic complications, and insufficient delivery to the location of the thrombus. Magnetic nanoparticles (MNPs) have been proposed for targeting tPA delivery. It would be advantageous to develop an improved in vitro model of clot formation, to screen thrombolytic therapies that could be enhanced by addition of MNPs, and to test magnetic drug targeting at human-sized distances.